中央大学 小松研究室(生命分子化学)

研究業績Publications

写真の説明を入れます 写真の説明を入れます 写真の説明を入れます 写真の説明を入れます 写真の説明を入れます 写真の説明を入れます 写真の説明を入れます 写真の説明を入れます 写真の説明を入れます 写真の説明を入れます 写真の説明を入れます 写真の説明を入れます

論文誌の表紙を飾った最近の研究成果

原著論文・総説(2010~)

Polyoxazoline-Conjugated L-Asparaginase: An Antibody-Production-Free Therapeutic Agent for Acute Lymphoblastic Leukemia
T. Yamada, M. Ishimaru, T. Shoji, H. Tomiyasu, R. Tochinai, K. Taguchi, T. Komatsu
ACS Appl. Bio Mater. 2023, 6, 5789−5797. AbstractNEW

Neuroprotective Effects of a Hemoglobin-Based Oxygen Carrier (Stroma-Free Hemoglobin Nanoparticle) on Ischemia Reperfusion Injury
R. Tatezawa, T. Abumiya, Y. Ito, M. Gekka, W. Okamoto, K. Ishii, N. Kohyama, T. Komatsu, M. Fujimura
Brain Res. 2023, 1821, 148953:1-10. AbstractNEW

Protein-Porphyrin Complex Photosensitizers for Anticancer and Antimicrobial Photodynamic Therapies [Short Review]
T. Yamada, T. Komatsu
ChemMedChem 2023, 18, e202300373:1-8. AbstractNEW

Pharmaceutical Stability of Methemoglobin-Albumin Cluster as an Antidote for Hydrogen Sulfide Poisoning after One-Year Storage in Freeze-Dried Form
Y. Suzuki, K. Taguchi, W. Okamoto, Y. Enoki, T. Komatsu, K. Matsumoto
Int. J. Pharm. 2023, 645, 123433:1-8. Abstract

Poly(2-ethyl-2-oxazoline)-Conjugated Hemoglobin as a Red Blood Cell Substitute
W. Okamoto, Y. Hiwatashi, T. Kobayashi, Y. Morita, H. Onozawa, M. Iwazaki, M. Kohno, H. Tomiyasu, R. Tochinai, R. Georgieva, H. Bäumler, T. Komatsu
ACS Appl. Bio Mater. 2023, 6, 3330−3340. Abstract

Pharmaceutical Integrity of Lyophilized Methemoglobin-Albumin Clusters after Reconstitution
Y. Suzuki, K. Taguchi, W. Okamoto, Y. Enoki, T. Komatsu, K. Matsumoto
ACS Omega 2023, 8, 22589−22595. Abstract
 ・ Open Access Article

Polyoxazoline-Conjugated Porcine Serum Albumin as an Artificial Plasma Expander for Dogs
W. Okamoto, T. Usui, M. Hasegawa, T. Kobayashi, J. Fujisawa, K. Taguchi, K. Matsumoto, M. Kohno, M. Iwazaki, S. Shimano, I. Nagao, H. Toyoda, N. Matsumura, H. Tomiyasu, R. Tochinai, T. Komatsu
Sci. Rep. 2023, 13, 9512:1-15. Abstract
 ・ Open Access Article

O2 Affinities of Hemoglobin Variants Having a Different Amino Acid at the Position α99
Y. Morita, R. Yoshida, A. Saito, T. Komatsu
Chem. Lett. 2023, 52, 325−328. Abstract

Methemoglobin-Albumin Clusters for Cyanide Detoxification
Y. Suzuki, K. Taguchi, W. Okamoto, Y. Enoki, T. Komatsu, K. Matsumoto
Toxicol. Appl. Pharmacol. 2023, 466, 116472:1-7. Abstract

Zinc Substituted Myoglobin‒Albumin Fusion Protein: A Photosensitizer for Cancer Therapy
T. Yamada, Y. Morita, R. Takada, M. Funamoto, W. Okamoto, M. Kohno, T. Komatsu
Chem. Eur. J. 2023, 29, e202203952:1-7. Abstract

Core-Shell Structured Hemoglobin Nanoparticles as Artificial O2 Carriers
W. Okamoto, M. Hasegawa, N. Kohyama, T. Kobayashi, T. Usui, H. Onozawa, R. Hashimoto, M. Iwazaki, M. Kohno, R. Georgieva, H. Bäumler, T. Komatsu
ACS Appl. Bio Mater. 2022, 5, 5844−5853. Abstract
 ・ Cover Image 

(ヘモグロビン-アルブミン)クラスター型人工酸素運搬体の開発
小松晃之
2022, 47, 252−256. AbstractNEW

Swimming Protein Microtube Motors Capture Virus-Shaped Fluorescent Nanoparticles
Y. Akashi, N. Sugai, R. Kato, T. Komatsu
Mater. Adv. 2022, 3, 6988−6992. Abstract
 ・ Open Access Article

Methemoglobin-Albumin Clusters for the Treatment of Hydrogen Sulfide Intoxication
Y. Suzuki, K. Taguchi, W. Okamoto, Y. Enoki, T. Komatsu, K. Matsumoto
J. Control. Release 2022, 349, 304−314. Abstract

Catalase–Albumin Cluster Incorporating Protoporphyrin IX: An O2 Generating Photosensitizer for Enhanced Photodynamic Therapy
T. Yamada, M. Katsumi, Y. Yagisawa, M. Ichihara, T. Komatsu
Mater. Adv. 2022, 3, 6451−6457, Abstract
 ・ Open Access Article
 ・ Cover Image 

Hemoglobin–Albumin Clusters as an Artificial O2 Carrier: Physicochemical Properties and Resuscitation from Hemorrhagic Shock in Rats
W. Okamoto, M. Hasegawa, T. Usui, T. Kashima, S. Sakata, T. Hamano, H. Onozawa, R. Hashimoto, M. Iwazaki, M. Kohno, T. Komatsu
J. Biomed. Mater. Res. 2022, 110, 1827−1838. Abstract

Polyelectrolyte/Gold Nanoparticle Nanotube Incorporating Doxorubicin-Loaded Liposomes
Y. Enomoto, M. Akiyama, Y. Morita, T. Komatsu
Chem. Asian J. 2021, 16, 4057−4061. Abstract

Protein Triad Comprising Genetically Fused Hemoglobin and Human Serum Albumins as an Artificial O2 Carrier Resistant to Haptoglobin Binding
Y. Morita, Y. Shindo, T. Komatsu
Chem. Lett. 2021, 50, 2011−2014. Abstract

Catalase-Driven Protein Microtube Motors with Different Exterior Surfaces as Ultrasmall Biotools
M. Umebara, N. Sugai, K. Murayama, T. Sugawara, Y. Akashi, Y. Morita, R. Kato, T. Komatsu
Mater. Adv. 2021, 2, 6428−6438. Abstract
Open Access Article

Genetically and Chemically Tuned Haemoglobin-Albumin Trimers with Superior O2 Transport Efficiency
Y. Morita, R. Takada, A. Saito, T. Komatsu
Chem. Commun. 2021, 57, 9144−9147. Abstract

Methemoglobin-Albumin Cluster Incorporating Protoporphyrin IX: Dual Functional Protein Drug for Photodynamic Therapy
T. Yamada, T. Komatsu
ChemBioChem 2021, 22, 2526−2529. Abstract

Halogen-Bonding-Donor Catalyzed Cyanosilylation of Aldehydes
K. Ueyama, S. Hayakawa, K. Nishio, D. Sawaguchi, K. Niitsuma, S. Michii, R. Tsuruoka, M. Ozawaa, K. Torita, Y. Morita, T. Komatsu, R. Haraguchi, S. Fukuzawa
Asian J. Org. Chem. 2021, 10, 1742−1747. Abstract

Acid Mediated Sulfonylthiolation of Arenes via Selective Activation of SS-Morpholino Dithiosulfonate
K. Kanemoto, K. Furuhashi, Y. Morita, T. Komatsu, S. Fukuzawa
Org. Lett. 2021, 23, 1582−1587. Abstract

Rectangular Holes in Porphyrin Isomers Act as Mono- and Binucleating Ligands: Stereochemistry of Mono- and Diboron Porphycenes and Their Protonation Behaviors
N. Xu, T. Ono, Y. Morita, T. Komatsu, Y. Hisaeda
Inorg. Chem. 2021, 60, 574−583. Abstract

Supramolecular Linear Coordination Polymers of Human Serum Albumin and Haemoglobin
R. Adachi, S. Suzuki, T. Mitsuda, Y. Morita, T. Komatsu
Chem. Commun. 2020, 56, 15585−15588. Abstract

Neuroprotective Effects of Combination Therapy of Regional Cold Perfusion and Hemoglobin-Based Oxygen Carrier Administration on Rat Transient Cerebral Ischemia
Y. Ito, T. Abumiya, T. Komatsu, R. Funaki, M. Gekka, K. Kurisu, T. Sugiyama, M. Kawabori, T. Osanai, N. Nakayama, K. Kazumata, K. Houkin
Brain Res. 2020, 1746, 147012:1‒8. Abstract

Protein-Based Smart Microtubes and Nanotubes as Ultrasmall Biomaterials [Highlight Review]
T. Komatsu
Chem. Lett. 2020, 49, 1245−1255. Abstract
 ・ Open Access Article
 ・ Front Cover   ・ Inside Cover 

水中で自走するタンパク質マイクロチューブモーター
小松晃之
高分子 2020, 69, 478−479. Abstract

Lewis Acid–Base Synergistic Catalysis of Cationic Halogen-Bonding-Donors with Nucleophilic Counter Anions
K. Torita, R. Haraguchi, Y. Morita, S. Kemmochi, T. Komatsu, S. Fukuzawa
Chem. Commun. 2020, 56, 9715−9718. Abstract

Haemoglobin(βK120C)-Albumin Trimer as Artificial O2 Carrier with Sufficiernt Haemoglobin Allostery
Y. Morita, A. Saito, J. Yamaguchi, T. Komatsu
RSC Chem. Biol. 2020, 1, 128−136. Abstract
 ・ Open Access Article
 ・ Cover Image 

Liophilized Hemoglobin-Albumin Cluster with Disaccharides: Long-Term Storable Powder of Artificial O2 Carrier
R. Funaki, H. Iwasaki, T. Kashima, T. Komatsu
Polym. Adv. Technol. 2020, 31, 1122−1126. Abstract

イヌ・ネコアルブミン製剤の開発と人工赤血球への応用
小松晃之、長谷川智美、森田能次
MVM (J. Modern Vet. Med.) 2020, 189, 102−107. Content

Genetically Engineered Haemoglobin Wrapped Covalently with Human Serum Albumins as an Artificial O2 Carrier
R. Funaki, W. Okamoto, C. Endo, Y. Morita, K. Kihira, T. Komatsu
J. Mater. Chem. B 2020, 8, 1139−1145. Abstract
 ・ Cover Image 

Protein Nanoparticles Formed by Self-Assembly of Human Serum Albumin with a Fatty Acid Arm
Y. Morita, D. Takahashi, T. Komatsu
Chem. Lett. 2020, 49,103−106. Abstract
 ・ Selected as an "Editor's Choice"
 ・ Open Access Article
 ・ Inside Cover 

Nonbubble-Propelled Biodegradable Microtube Motors Consisting Only of Protein
N. Sugai, Y. Morita, T. Komatsu
Chem. Asian J. 2019, 14, 2953−2957. Abstract
 ・ Selected as a "Very Important Paper" (VIP)

Protein Microtube Motors with a Pt Nanoparticle Interior and Avidin Exterior for Self-Propelled Transportation, Separation, and Stirring
Y. Nakai, N. Sugai, H. Kusano, Y. Morita, T. Komatsu
ACS Appl. Nano Mater. 2019, 2, 4891−4899. Abstract
 ・ Cover Image 

Hemoglobin(βC93A)-Albumin Cluster: Mutation of Cysteine-β93 to Alanine Allows Moderate Reduction of O2 Affinity by Inositol Hexaphosphate
Y. Morita, K. Igarashi, R. Funaki, T. Komatsu
ChemBioChem 2019, 20, 1684−1687. Abstract

Further Evidence Regarding the Important Role of Chlorine Atoms of Aripiprazole on Binding to the Site II Area of Human Albumin
K. Sakurama, K. Nishi, S. Imoto, M. Hashimoto, T. Komatsu, Y. Morita, K. Taguchi, M. Otagiri, K. Yamasaki
J. Pharm. Sci. 2019, 108, 1890−1895. Abstract

酵素反応で自走するマイクロチューブモーター ―バイオメディカル領域での応用を目指して
小松晃之、菅井夏穂
化学(化学同人)2019, 74, 66−67. Content

Hemoglobin-Albumin Clusters Prepared using N-Succinimidyl 3-Maleimidopropionate as an Appropriate Crosslinker
R. Funaki, T. Kashima, W. Okamoto, S. Sakata, Y. Morita, M. Sakata, T. Komatsu
ACS Omega 2019, 4, 3228−3233. Abstract
 ・ Open Access Article

Physicochemical Properties and Crystal Structures of Recombinant Canine and Feline Serum Albumins [Review]
T. Komatsu, K. Kihira, K. Yamada, K. Yokomaku, M. Akiyama, Y. Morita
Int. J. Microgravity Sci. Appl. 2019, 36, 360104:1−6. Abstract
 ・ Open Access Article

Hemoglobin-Albumin Cluster: Physiological Responses after Exchange Transfusion into Rats and Blood Circulation Persistence in Dogs
H. Iwasaki, K. Yokomaku, M. Kureishi, K. Igarashi, R. Hashimoto, M. Kohno, M. Iwazaki, R. Haruki, M. Akiyama, K. Asai, Y. Nakamura, R. Funaki, Y. Morita, T. Komatsu
Artif. Cells Nanomed. Biotechnol. 2018, 46, S621−S629. Abstract

Quaternary Structure Analysis of a Hemoglobin Core in Hemoglobin-Albumin Cluster
Y. Morita, T. Yamada, M. Kureishi, K. Kihira, T. Komatsu
J. Phys. Chem. B 2018, 122, 12031−12039. Abstract

Stratiform Protein Microtube Reactors Containing Glucose Oxidase Layer
R. Adachi, M. Akiyama, Y. Morita, T. Komatsu
Chem. Asian J. 2018, 13, 2796−2799. Abstract

Bulky Iodotriazolium Tetrafluoroborates as Highly Active Halogen-Bonding-Donor Catalysts
R. Haraguchi, S. Hoshino, M. Sakai, S. Tanazawa, Y. Morita, T. Komatsu, S. Fukuzawa
Chem. Commun. 2018, 54, 10320−10323. Abstract

Transparent Protein Microtubule Motors with Controllable Velocity and Biodegradability
N. Sugai, Y. Nakai, Y. Morita, T. Komatsu
ACS Appl. Nano Mater. 2018, 1, 3080−3085. Abstract
 ・ Cover Image 

A Novel Hemoglobin-Based Oxygen Carrier Bound with Albumin Shows Neuroprotection with Possible Antioxidant Effects
M. Gekka, T. Abumiya, T. Komatsu, R. Funaki, K. Kurisu, D. Shimbo, M. Kawabori, T. Osanai, N. Nakayama, K. Kazumata, K. Houkin
Stroke 2018, 49, 1960−1968. Abstract

Core-Shell Protein Clusters Comprising Haemoglobin and Recombinant Feline Serum Albumin as an Artificial O2 Carrier for Cats
K. Yokomaku, M. Akiyama, Y. Morita, K. Kihira, T. Komatsu
J. Mater. Chem. B 2018, 6, 2417−2425. Abstract
 ・ Highlighted by Chemistry World
 ・ Cover Image  

Self-Propelled Soft Protein Microtubes with a Pt Nanoparticle Interior Surface
S. Kobayakawa, Y. Nakai, M. Akiyama, T. Komatsu
Chem. Eur. J. 2017, 23, 5044−5050. Abstract
 ・ Highlighted by Chemistry World
 ・ Cover Image 

Structural Insights into a Hemoglobin-Albumin Cluster in Aqueous Medium
R. Shinohara, T. Yamada, B. Schade, C. Böttcher, T. Sato, N. Sugimura, T. Shibue, T. Komatsu
J. Phys. Chem. Lett. 2017, 8, 819−824. Abstract
 ・ Featured in Spotlights

Glycoprotein Nanotube Traps Influenza Virus
S. Yuge, M. Akiyama, M. Ishii, H. Namkoong, K. Yagi, Y. Nakai, R. Adachi, T. Komatsu
Chem. Lett. 2017, 46, 95−97. Abstract
 ・ Selected as an "Editor's Choice"
 ・ Open Access Article

Artificial Blood for Dogs
K. Yamada, K. Yokomaku, M. Kureishi, M. Akiyama, K. Kihira, T. Komatsu
Sci. Rep. 2016, 6, 36782:1−11. Abstract
 ・ Open Access Article

Influence of Molecular Strcuture on O2-Binding Properties and Blood Circulation of Hemoglobin-Albumin Clusters
K. Yamada, K. Yokomaku, R. Haruki, K. Taguchi, S. Nagao, T. Maruyama, M. Otagiri, T. Komatsu
PLoS One 2016, 11, e149526:1-15. Abstract
 ・ Open Access Article

Highly Sensitive Detection of Organophosphorus Pesticides using 5,10,15,20-Tetrakis(4-hydroxyphenyl)porphyrin
T. Murakami, Y. Iwamuro, S. Chinaka, N. Takayama, T. Komatsu
Anal. Sci. 2015, 31, 1325−1328. Abstract
 ・ Open Access Article

Nanotube Reactor with a Lipase Wall Interior for Enzymatic Ring-Opening Oligomerization of Lactone
Y. Amano, T. Komatsu
Chem. Lett. 2015, 44, 1646−1648. Abstract

Safety Evaluation of Hemoglobin-Albumin Cluster "HemoAct" as a Red Blood Cell Substitute
R. Haruki, T. Kimura, H. Iwasaki, K. Yamada, I. Kamiyama, M. Kohno, K. Taguchi, S. Nagao, T. Maruyama, M. Otagiri, T. Komatsu
Sci. Rep. 2015, 5, 12778:1-9. Abstract
 ・ Open Access Article

Core-Shell Clusters of Human Haemoglobin A and Human Serum Albumin: Artificial O2-Carriers Having Various O2-Affinities
T. Kimura, R. Shinohara, C. Böttcher, T. Komatsu
J. Mater. Chem. B 2015, 3, 6157−6164. Abstract
 ・ Open Access Article
 ・ Cover Image 

Cross-Linked Human Serum Albumin Dimer has the Potential for Use as a Plasma-Retaining Agent for the Fatty Acid-Conjugated Antidiabetic Drugs
K. Taguchi, V. Chuang, K. Yamasaki, Y. Urata, R. Tanaka, M. Anraku, H. Seo, K. Kawai, T. Maruyama, T. Komatsu, M. Otagiri
J. Pharm. Pharmacol. 2015, 67, 255−263. Abstract

Hemoglobin-Albumin Cluster Incorporating a Pt Nanoparticle: Artificial O2 Carrier with Antioxidant Activities
H. Hosaka, R. Haruki, K. Yamada, C. Böttcher, T. Komatsu
PLoS One 2014, 9, e110541:1-9. Abstract
 ・ Open Access Article

Haemoglobin Wrapped Covalently by Human Serum Albumin Mutants Containing Mn(III) Protoporphyrin IX: An O2 Complex Stable in H2O2 Solution
Y. Daijima, T. Komatsu
Chem. Commun. 2014, 50, 14716−14719. Abstract
 ・ Open Access Article
 ・ Cover Image 

人工酸素運搬体(赤血球代替物)の開発 =せまりくる"血液不足"の危機を乗り越えるための切り札=
小松晃之
化学と工業 2014, 67, 677−679. Contents

An Escherichia coli Trap in Human Serum Albumin Microtubes
S. Yuge, M. Akiyama, T. Komatsu
Chem. Commun. 2014, 50, 9640−9643. Abstract
 ・ Open Access Article
 ・ Highlighted by Chemistry World
 ・ Cover Image 

Fluorescence Dimer and Fiber of meso-Tetrakis{o-(isonicotinoylamino)phenyl}porphyrin Connected by Pd(II) Coordinations
S. Kasuya, Y. Yamazawa, N. Sugimura, T. Shibue, T. Komatsu
Chem. Lett. 2014, 43, 1008−1010. Abstract
 ・ Open Access Article

Size-Dependent Dextran Loading in Protein Nanotube with an Interior Wall of Concanavalin A
Y. Shiraishi, M. Akiyama, T. Sato, M. Hattori, T. Komatsu
Polym. Adv. Technol. 2014, 25, 1247−1251. Abstract

Superoxide Dismutase Activity of the Naturally Occurring Human Serum Albumin-Copper Complex without Hydroxyl Radical Formation
R. Kato, M. Akiyama, H. Kawakami, T. Komatsu
Chem. Asian J. 2014, 8, 83−86. Abstract

Gold Nanoparticle Inclusion into Protein Nanotubes as a Layered Wall Component
S. Goto, Y. Amano, M. Akiyama, C. Böttcher, T. Komatsu
Langmuir 2013, 29, 14923−14930. Abstract

Human Serum Albumin Mutants Complexed Mn(III) Protoporphyrin IX as Superoxide Dismutase Mimics
R. Kato, Y. Kobayashi, M. Akiyama, T. Komatsu
Dalton Trans. 2013, 42, 15889−15892. Abstract

Covalent Core-Shell Architecture of Hemoglobin and Human Serum Albumin as an Artificial O2 Carrier
D. Tomita, T. Kimura, H. Hosaka, Y. Daijima, R. Haruki, K. Ludwig, C. Böttcher, T. Komatsu
Biomacromolecules 2013, 14, 1816−1825. Abstract

Structure and Photocatalytic Activity of Iron Oxide Nanotubes Prepared from Ferritin
R. Kato, T. Komatsu
J. Inorg. Organomet. Polym. 2013, 23, 167−171. Abstract

Human Serum Albumin-Based Peroxidase Having an Iron Protoporphyrin IX in Artificial Heme Pocket
K. Watanabe, N. Isihikawa, T. Komatsu
Chem. Asian J. 2012, 7, 2534−2537. Abstract

Protein-Based Nanotubes for Biomedical Applications [Feature Article]
T. Komatsu
Nanoscale 2012, 4, 1910−1918. Abstract
 ・ Cover Image 

Human Serum Albumin Nanotubes with Esterase Activity
T. Komatsu, T. Sato, C. Böttcher
Chem. Asian J. 2012, 7, 201−206. Abstract

Protein Nanotube Arrays Immobilized on Solid Substrates: Molecular Trap in Aqueous Medium
R. Kato, T. Komatsu
Chem. Lett. 2011, 40, 1338−1339. Abstract

Virus Trap in Human Serum Albumin Nanotube
T. Komatsu, X. Qu, H. Ihara, M. Fujihara, H. Azuma, H. Ikeda
J. Am. Chem. Soc. 2011, 133, 3246−3248. Abstract
 ・ Highlighted by Chemistry World

Protein Nanotubes Bearing a Magnetite Surface Exterior
T. Komatsu, N. Kobayashi
Polym. Adv. Technol. (Prof. E. Tsuchida Special Issue) 2011, 22, 1315−1318. Abstract

Protein Nanotubes with an Enzyme Interior Surface
T. Komatsu, H. Terada, N. Kobayashi
Chem. Eur. J. 2011, 17, 1849−1854. Abstract

Superior Plasma Retension of a Cross-Linked Human Serum Albumin Dimer in Nephrotic Rats as a New Type of Plasma Expander
K. Taguchi, Y. Urata, M. Anraku, H. Watanabe, K. Kawai, T. Komatsu, E. Tsuchida, T. Maruyama, M. Otagiri
Drug Metab. Dispos. 2010, 38, 2124−2129. Abstract

Molecular Insight of Intrinsic Heme Distortion to the Ligand Binding in Hemoprotein
S. Neya, M. Suzuki, T. Hoshino, H. Ode, K. Imai, T. Komatsu, A. Ikezaki, M. Nakamura, Y. Furutani, H. Kandori
Biochemistry 2010, 49, 5642−5650. Abstract

Solid Nanotubes Comprising α-Fe2O3 Nanoparticles Prepared from Ferritin Protein
X. Qu, N. Kobayashi, T. Komatsu
ACS Nano 2010, 4, 1732−1738. Abstract

Molecular Capture in Protein Nanotubes
X. Qu, T. Komatsu
ACS Nano 2010, 4, 563−573. Abstract
 ・ Highlighted by Nanowerk


2000−2009年の論文・総説

2000年以前の論文・総説は省略


著 書(分担執筆)

ヘモグロビンを用いた人工酸素運搬体(赤血球代替物)の開発
小松晃之
ヘムタンパク質の科学 ~生理機能の理解とその展開に向けて~、監修:城 宜嗣、青野重利、齋藤正男、p. 407−413、エヌ・ティー・エス(東京、2022ContentNEW

赤血球代替物となる人工酸素運搬体の開発
森田能次、小松晃之
錯体化学会フロンティア選書「フロンティア機能高分子金属錯体」、編著:西原 寛、山元公寿、p. 300−323、三共出版(東京、2020Content

Hemoglobin-Albumin Clusters as a Red Blood Cell Substitute
T. Komatsu
Albumin in Medicine. Pathological and Clinical Applications, Ed. M. Otagiri, V. T. Giam Chuang, p. 165−178 (Chapter 9), Springer (Tokyo, 2016) Abstract

タンパク質ナノチューブの合成と応用展開
小松晃之、秋山元英
超分子材料の設計と応用展開、監修:原田 明、p. 64−71、シーエムシー出版(大阪、2014

Albumin-Heme Oxygen Carriers
T. Komatsu
Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics, Ed. H. W. Kim, A. G. Greenburg, p. 339−348 (Chapter 18), Springer-Verlag (Berlin Heidelberg, 2013) Abstract

Albumin-Heme as an O2-Carrying Plasma Protein
T. Komatsu
Human Serum Albumin −New Insights on its Structural Dynamics, Functional Impacts and Pharmaceutical Applications, Ed. M. Otagiri, p. 332−345 (Chapter 17), Sojo Univ. Pub. (Kumamoto, 2013)

交互積層法による蛋白質ナノチューブの合成
小松晃之
有機・無機・金属ナノチューブ-非カーボンナノチューブ系の最新技術と応用展開、清水敏美、木島 剛 編、p. 82−88、フロンティア出版(東京、2008

Albumin-Heme: A Synthetic Heme-Based Oxygen Carrier
T. Komatsu, Y. Huang, H. Yamamoto, H. Horinouchi, K. Kobayashi, E. Tsuchida
Blood Substitutes, Ed. R. Winslow, p. 532−539 (Chapter 46), Elsevier (London, 2006)

Oxygen-Carrying Plasma Hemoprotein Including Synthetic Heme
T. Komatsu, E. Tsuchida
Artificial Oxygen Carrier. Its Front Line, Eds. K. Kobayashi, E. Tsuchida, H. Horinouchi, p. 193−204, Springer-Verlag (Tokyo, 2005)

Safety and Efficacy of Hemoglobin-Vesicles and Albumin-Hemes
K. Kobayashi, H. Horinouchi, M. Watanabe, Y. Izumi, Y. Teramura, A. Nakagawa, Y. Huang, K. Sou, H. Sakai, T. Komatsu, S. Takeoka, E. Tsuchida
Artificial Oxygen Carrier. Its Front Line, Eds. K. Kobayashi, E. Tsuchida, H. Horinouchi, p. 1−21, Springer-Verlag (Tokyo, 2005)

疎水ポルフィリン組織体の構築と酸素の運搬
西出宏之、小松晃之、土田英俊
ソフトマテリアルの新展開, 監修:西 敏夫、p. 16−26、シーエムシー出版(東京、2004


2003年以前の著書は省略